I had one of those in my first truck, it was nice with a good sound, and no tuning changes were required. the stock y is usually fairly far in front of where the muffler goes, and to the best of my knowledge, most shops put the new muffler in the same spot as the old one, which is a few feet away from the stock Ypipe.
I dont think it will be a problem, but if you are too worried, then I would recommend calling Bill and asking him.
Hope that helps