Can I custom tune a PHP custom tune?

[Evil150]

Probably a bad way of describing it in the title but when I go to my custom 91 performance tune on my Gryphon it asks if I would like to make any custom changes, then the whole PHP is not responsible message shows up. Would it be bad for me to firm up my shifts or adjust the WOT Throttle? How can I make my custom 91 tune more aggressive? I have an Airaid intake, and Super 44 muffler on my 05 5.4L F-150 on 22's... Just wanted to know if anyone has any recommendations? Thanks!